The Role of Splenectomy in The Treatment of β-Thalassemia Major Patients: A literature review

Thalassemia is a group of inherited blood disorders due to the reduction or absence globin chain synthesis which can cause hemolytic anemia. β-thalassemia major severe type thalassemia, in patients require lifelong transfusions for survival. Extravascular hemolysis on spleen results splenomegaly, meanwhile, extramedullary hematopoiesis causing hypersplenism develop beta-thalassemia patients. Hypersplenism, symptomatic and increased annual need transfusion thalassemia are indicators splenectomy. However, aside from benefit splenectomy may reduce people with goal reducing iron overload, it also be linked several negative effects that outweigh any benefits, such as postoperative infections high mortality rate thrombotic events.